How Would the Reverend Bayes Interpret High-Sensitivity Troponin?
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منابع مشابه
How would the Reverend Bayes interpret high-sensitivity troponin?
Cardiac troponins are heavily relied on in the laboratory evaluation of patients with suspected myocardial infarction (MI) because of their putative high sensitivity and specificity for detection of myocardial necrosis. According to the National Academy of Clinical Biochemistry guidelines, “In the presence of a clinical history suggestive of acute coronary syndrome, maximal concentration of car...
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Cardiac troponin (cTn) testing is an essential component of the diagnostic workup and management of acute coronary syndromes (ACS). Although over the past 15 years the diagnostic performance of the previous gold-standard assay, creatine kinaseMB, has not changed appreciably, the ever-increasing sensitivity of cTn assays has had a dramatic impact on the use of cTn testing to diagnose ACS.1 Here,...
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A defining feature of modern science is scepticism: the philosophical position that nothing can be known with complete certainty. All scientific hypotheses are open to challenge. However, although every hypothesis is uncertain, some are held to be more uncertain than others. Hypotheses and scientific models supported by a vast weight of evidence are considered more likely to represent reality c...
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High sensitivity troponin (hsTn) assays provide an unprecedented opportunity to improve the detection and treatment of cardiac injury from coronary and non-coronary causes. They may also play a role in guiding the primary and secondary prevention of cardiovascular disease. However, to derive maximal benefit from their use, careful planning for the implementation of these new assays is required....
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The Reverend Bayes (1702–1761) has become well known for his Theorum, and developed a following of statisticians and their hangers-on who declare themselves to be ‘Bayesians’. Does his contribution merit the enthusiasms of his followers? Or is his legacy overhyped? Bayes did not publish any mathematical work during his lifetime under his own name, and indeed his major attributed work was appare...
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ژورنال
عنوان ژورنال: Circulation
سال: 2010
ISSN: 0009-7322,1524-4539
DOI: 10.1161/cir.0b013e3181d839e8